ENGINEERING
GENOME
TRANSFORMING
LIVES
At the RNA Biology Lab, we are pioneering innovative genome engineering solutions, utilizing advanced CRISPR-Cas9 technologies to develop curative therapies for a broad range of genetic disorders, including hemoglobinopathies like Sickle Cell Disease and Duchenne Muscular Dystrophy. Our research also explores cutting-edge point-of-care diagnostics and investigates RNA signatures that influence embryonic stem cell fate and neuronal migration, combining bioengineering and imaging approaches to reveal complex regulatory mechanisms. By integrating cerebral organoid models and CRISPR-engineered assembloids, we aim to elucidate disease mechanisms and advance personalized therapeutic interventions.
The RNA Biology Lab works in close collaboration with Dr. Souvik Maiti's Lab, in advancing CRISPR based therapeutics
Our lab is dedicated to driving transformative advances in RNA biology and genome editing, fostering collaborative research, and nurturing the next generation of scientific leaders.
Building Brains in the Lab
We are leveraging Cas9 gene editing to engineer customized 3D brain organoids, providing unprecedented insights into complex neurological disorders influenced by intraneuron migration assemblies. Our research advances the understanding of brain disease mechanisms and investigating neurodevelopmental processes
Gene Editing for Hemoglobinopathies
Harnessing the power of engineered CRISPR systems, we are pioneering futuristic therapies to cure hemoglobinopathies like Sickle Cell Anemia and Thalassemia at the molecular level, offering curative potential beyond conventional treatments and revolutionizing precision medicine. Our mission is to merge scientific innovation with therapeutic affordability, making gene editing cures accessible to even the most underserved populations.
Next-Gen CRISPR Diagnostics
Utilizing the power of FELUDA (FnCas9 Editor Linked Uniform Detection Assay), we have developed an innovative paper strip diagnostic system for rapid and affordable detection of multiple diseases, including SARS-CoV-2, showcasing the potential of CRISPR technology for scalable point-of-care diagnostics. Commercially launched as TataMD Check, it is the world’s first CRISPR-enabled paper strip test to receive regulatory approval.
Latest Publications
MLC1 alteration in iPSCs give rise to disease-like cellular vacuolation phenotype in the astrocyte lineage | Pre-print 2025
Saumya Sharma1, Vishal Bharti, Prosad Kumar Das, Abdul Rahman, Harshita Sharma, Riya Rauthan, Madhumita RC, Neerja Gupta, Rashmi Shukla, Sujata Mohanty, Madhulika Kabra, Kevin R Francis, Debojyoti Chakraborty
Emerging opportunities for gene editing therapies in India | Nature Medicine 2024
Debojyoti Chakraborty, Souvik Maiti, Arkosubhra Ghosh
Engineered FnCas9 mediated mutation profiling for clarithromycin resistance in Helicobacter pylori strains isolated from Indian patients with gastrointestinal disorders | Microchemical Journal 2024
Shraddha Chakraborty , Shubham Rana, Sneha Gulati, Shubham Chaudhary, Manas K. Panigrahi, Vinay K. Hallur, Souvik Maiti, Debojyoti Chakraborty, Govind K. Makharia
Deciphering the Thermodynamic Landscape of CRISPR/Cas9: Insights into Enhancing Gene Editing Precision and Efficiency | The Journal of Physical Chemistry B 2024
Ajit Kumar, Purba Daripa, Kaiser Rasool, Debojyoti Chakraborty, Niyati Jain, Souvik Maiti
PAM-flexible Engineered FnCas9 variants for robust and ultra-precise genome editing and diagnostics | Nature Communications 2024
Sundaram Acharya, Asgar Hussain Ansari, Prosad Kumar Das, Seiichi Hirano, Meghali Aich, Riya Rauthan, Sudipta Mahato, Savitri Maddileti, Sajal Sarkar, Manoj Kumar, Rhythm Phutela, Sneha Gulati, Abdul Rahman, Arushi Goel, C Afzal, Deepanjan Paul, Trupti Agrawal, Vinay Kumar Pulimamidi, Subhadra Jalali, Hiroshi Nishimasu, Indumathi Mariappan, Osamu Nureki, Souvik Maiti, Debojyoti Chakraborty
FUNDING
Lady Tata Memorial Trust
(LTMT)
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MERCK Young Scientist Award
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European Molecular Biology Organization
Council of Scientific & Industrial Research
(CSIR)
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Ministry of Tribal Affairs
Government of India
Department of S&T
Ministry of S&T
Government of India
Department of Biotechnology
Ministry of S&T
Government of India
GALLERY
