Latest Publications
MLC1 alteration in iPSCs give rise to disease-like cellular vacuolation phenotype in the astrocyte lineage | Pre-print 2025
Saumya Sharma, Vishal Bharti, Prosad Kumar Das, Abdul Rahman, Harshita Sharma, Riya Rauthan, Madhumita RC, Neerja Gupta, Rashmi Shukla, View ORCID ProfileSujata Mohanty, Madhulika Kabra, Kevin R Francis, Debojyoti Chakraborty
Emerging opportunities for gene editing therapies in India | Nature Medicine 2024
Debojyoti Chakraborty, Souvik Maiti, Arkosubhra Ghosh
Engineered FnCas9 mediated mutation profiling for clarithromycin resistance in Helicobacter pylori strains isolated from Indian patients with gastrointestinal disorders | Microchemical Journal 2024
Shraddha Chakraborty, Shubham Rana, Sneha Gulati, Shubham Chaudhary, Manas K. Panigrahi, Vinay K. Hallur, Souvik Maiti, Debojyoti Chakraborty, Govind K. Makharia
Deciphering the Thermodynamic Landscape of CRISPR/Cas9: Insights into Enhancing Gene Editing Precision and Efficiency | The Journal of Physical Chemistry B 2024
Ajit Kumar, Purba Daripa, Kaiser Rasool, Debojyoti Chakraborty, Niyati Jain, Souvik Maiti
PAM-flexible Engineered FnCas9 variants for robust and ultra-precise genome editing and diagnostics | Nature Communications 2024
Sundaram Acharya 1 2, Asgar Hussain Ansari, Prosad Kumar Das, Seiichi Hirano, Meghali Aich, Riya Rauthan , Sudipta Mahato, Savitri Maddileti, Sajal Sarkar, Manoj Kumar, Rhythm Phutela, Sneha Gulati, Abdul Rahman, Arushi Goel, C Afzal, Deepanjan Paul, Trupti Agrawal, Vinay Kumar Pulimamidi, Subhadra Jalali, Hiroshi Nishimasu, Indumathi Mariappan, Osamu Nureki, Souvik Maiti, Debojyoti Chakraborty
Rare genetic disorders in India: Current status, challenges, and CRISPR-based therapy | Journal of Biosciences 2024
Pallabi Bhattacharyya, Kanikah Mehndiratta, Souvik Maiti & Debojyoti Chakraborty
An interface of genetically engineered human forebrain assembloids and polymeric nanofiber scaffolds for multiscale profiling of interneuron migration disorders | Pre-print 2024
Riya Rauthan1, Vishal Bharti1, Atharva Agashe, Praveen Singhu, Harrison M York, Amrinder S. Nain, Senthil Arumugam, Debojyoti Chakraborty1
2023
TOBF1 modulates mouse embryonic stem cell fate through regulating alternative splicing of pluripotency genes | Cell Reports 2023
CriSNPr: a single interface for the curated and de novo design of gRNAs for CRISPR diagnostics using diverse Cas systems | Elife 2023
Asgar H Ansari, Manoj Kumar, Sajal Sarkar, Souvik Maiti, Debojyoti Chakraborty
Identification of G-quadruplex structures in MALAT1 lncRNA that interact with nucleolin and nucleophosmin | Nucleic Acids Research 2023
Arpita Ghosh, Satya Prakash Pandey, Dheeraj Chandra Joshi, Priya Rana, Asgar Hussain Ansari, Jennifer Seematti Sundar, Praveen Singh, Yasmeen Khan, Mary Krishna Ekka, Debojyoti Chakraborty, Souvik Maiti
2022
FnCas9 Editor Linked Uniform Detection Assay for COVID 19 | Multiplex Biomarker Techniques, Springer 2022
Rhythm Phutela, Sneha Gulati, Manoj Kumar, Souvik Maiti, Debojyoti Chakraborty.
Capturing nucleic acid variants with precision using CRISPR diagnostics | Multiplex Biomarker Techniques, Springer 2022
Commentary: Artificial intelligence-based screening of retina | Indian Journal of Opthalmology 2022
Visualization of 3D Organoids Through the Latest Advancements in Microscopy | Brain Organoid Research 2022
Manoj Kumar, Riya Rauthan, Debojyoti Chakraborty, Senthil Arumugam
2021
RAY: CRISPR diagnostic for rapid and accurate detection of SARS-CoV2 variants on a paper strip | MedRxiv
Rapid and accurate nucleobase detection using FnCas9 and its application in COVID-19 diagnosis | Biosensors and Bioelectronics
CRISPR Cas9 based genome editing in inherited retinal dystrophies | Ophthalmic Genetics
Low-cost CRISPR diagnostics for resource-limited settings | Trends in Genetics
Voices of biotech research | Nature Biotechnology
Rapid identification and tracking of SARS-CoV-2 variants of concern | The Lancet
2020
Ophthalmic genetics practice and research in India: Vision in 2020 | American Journal of Medical Genetics. Partc C, seminars in Medical Genetics
Terminal uridylyl transferase-mediated site-directed access to clickable chromatin employing CRISPR-dCas9 | Journal of the American Chemical Society
Role of lncRNAs in stem cell maintenance and differentiation | Current Topics in Developmental Biology
The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells | Life Science Alliance
Li Ding, Maciej Paszkowski-Rogacz, Jovan Mircetic, Debojyoti Chakraborty, Frank Buchholz
Before 2020
Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing | Proceedings of the National Academy of Sciences 2019
Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma | Scientific Reports 2018
A G-quadruplex motif at the 3’ end of sgRNAs improves CRISPR-Cas9-based genome editing efficiency | Chemical Communications 2018
LncRNA Panct1 maintains mouse embryonic stem cell identity by recruiting TOBF1 to Oct-Sox sequences in early G1 | Cell Reports 2017
CRISPR-Cas9: a new tool for gene therapy | eLS 2017
CRISPR/Cas9: a historical and chemical biology perspective of targeted genome engineering | Chemical Society Reviews 2016
Inactivation of cancer mutations utilizing CRISPR/Cas9 | Journal of the National Cancer Institute 2016
Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity | Nature Biotechnology 2016
Targeting Human Long-Noncoding Transcripts by Endoribonuclease-prepared siRNAs | Journal of Biomolecular Screening 2015
Mirko Theis, Maciej Paszkowski-Rogacz, Ina Weisswange, Debojyoti Chakraborty, Frank Buchholz
Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells | Cell Systems 2015
Universal Tre (uTre) recombinase specifically targets the majority of HIV-1 isolates | Journal of the International AIDS Society 2014
Combined RNAi and localization for functionally dissecting long noncoding RNAs | Nature Methods 2012